In Vitro Chromosomal Aberration Assay

Key Features of Our Tests

• Reproducible and Consistent data

• Rapid turnaround time (10 business days)

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The chromosomal aberration test is designed to evaluate the potential of a test compound to induce structural chromosomal abnormalities, such as breaks and exchanges.

Chromosomal Aberration Test Procedure

• The chromosomal aberration test can be performed in primary human peripheral blood lymphocytes (HPBL) or established cell lines, such as Chinese hamster ovary (CHO) cells.

• Cultures are incubated with several doses of the test compound for 4 hours in the presence of S9 metabolic activation system and for 24 hours in the absence of S9.

• A positive outcome is characterized by a statistically significant, dose-dependent increase in aberrant cells.